IL-6 is also known to prevent diabetes in predisposed mammals, but it has the added advantage of preventing the autoimmunity that TNF-alpha can sometimes promote. Thus, increases in both TNF-alpha and IL-6 in response to immune support with vitalethine in mAIDS-infected mice, also is exactly the immune response needed to prevent diabetes in predisposed mammals. These combined effects ultimately help to target the humoral response to specifically attack the immune challenge, after which the body slacks off on antibody production until the same or similar challenge arises again. Such immune memory is the “vaccination” conveying lifetime immunity and prevent disease recurrence.