This article characterizing the disastrous effects that toxic, sulfur-binding metals have upon estrogen receptors in human breast cancer cells came out in 2003, some seven years after we started warning people about the dangers of metals that bind sulfur chemistry. Results in cell culture don't always reflect concerns in the whole body, since there are many buffers that help to protect the vitaletheine modulators from poisoning by metal toxins. R-dihydrolipoic acid most likely binds metal toxins tightly, and glutathione, metallothionine, insulin, and serum albumin are examples of proteins and peptides that have high L-cysteine and L-cystine contents, enabling their protective buffering while also being poisoned by metal toxins that bind sulfur.