Metal toxins bind to estrogen receptor chimeric constructs and activate expression of these receptors in breast cancer cells from 2 to 6 times, depending upon the metal used to contaminate the cultures of these cells. This means that metal toxins, especially those shown to bind tightly to the sulfur groups in the estrogen receptor, can cause breast cancer cells to divide at a much higher rate even when there is no estrogen present to stimulate them. Thus, metal toxicity becomes a major confounding problem in intractable breast cancers which do not respond to conventional “surgery, chemotherapy, and radiation.” Removing metal toxins from the body, while also supporting antibody-mediated (humoral) immunity is the best way to compensate for this.