Early Merck Indexes (8th edition) actually listed pangamic acid as vitamin B15, and lauded its ubiquitous distribution in seeds, brewers' yeast, ox blood, and horse liver. Although its actual structure really is not debatable, we are not as limited analytically, now, as the early pioneers in the field of biochemistry once were. Note that 1) “vitamin B15” reportedly helped cardiovascular and rheumatic diseases, and 2) that glycine and gluconic acid were mentioned among chemicals identified in the actual early preparations of pangamic acid. Since then, dimethylglycine has been made commercially-available in stable forms (individual foil packets). Organ transplants, autoimmunity, or hypersensitivity may preclude use of dimethylglycine and VSOH.